Ciclesonide side effects can occur even when this drug is used properly. The most common side effects of this medication include bloody nose, headache, fever, sore throat, nasal discomfort, muscle aches, stuffy nose, weakness, fatigue, and runny nose. Rare, but still possible, side effects include acne, burning of the skin, blurred vision, darkening of the skin, diarrhea, trouble breathing, dizziness, difficulty swallowing, fainting, eye pain, hives, loss of vision, loss of appetite, menstrual change, depression, nausea, wheezing, tightness in the chest, vomiting, and swelling of the face and eyes. If any of these side effects occur, consult a medical professional.