The ESR blood test can have an abnormal result for many reasons. Some of the conditions that can cause an abnormal result include chronic kidney disease, pregnancy, lupus and other autoimmune diseases, thyroid disease, and other conditions that cause inflammation of body tissues.
Some conditions cause extremely high ESR levels. These conditions include blood vessel death, giant cell arteritis, multiple myeloma, and increased blood fibrogen levels.
Some conditions can cause low ESR levels. These conditions include decreased fibrinogen, sickle cell anemia, and congestive heart failure. Most of these are severe conditions, so your doctor will need to follow you once your ESR test results come back from the laboratory.