Molecular Base of Obesity
Researchers at several different institutions, such as the University of Cincinnati in Ohio, believe that the Bsx molecule may be the key to battling obesity and feel that there is a molecular base for obesity. This molecule, found in the hypothalamus of the brain, is necessary for spontaneous physical activity, such as food intake and fidgeting, two factors that are essential in maintaining a healthy body weight. When someone is hungry, their spontaneous activity heightens, giving them the motivation to go out and get something to eat.
In a mice study, those who were lacking the Bsx molecule, were far lazier than the normal mice. These mice had very little desire to exercise, or do much moving at all. The differences in Bsx activity amongst different people could aid in explaining why some people are less vulnerable by diet-associated obesity and why some are inherently more active than others.
This information, and the studies concerning, are being conducted in hopes of finding a solid link between the Bsx molecule and obesity. Once this is done, scientists are hoping to turn the Bsx molecule into a drug target and continue research about how it may be successful in modulating basic physical activity to help protect individuals against diet-induced obesity.