Symptoms and Complications
Symptoms and complications of NPS can be unique to each patient. The most common place the symptoms appear is the fingers and fingernails. The most common symptom is abnormal or absent fingernails. Often, multiple fingers are affected; however, the toes are less likely to exhibit any symptoms. The nails, especially those on the index fingers and thumbs, often appear concave, contain splits or ridges, and discoloration.
The bones and joints are often affected by the condition as well. The kneecaps are the second most common area affected by the rare disorder. The kneecaps are either deformed or missing. They often easily dislocate and have a square appearance. The surrounding joints, bones, tendons, and ligaments can also be victims of deformities. This makes if very difficult for people with the condition to walk. The hip bones often contain bone spurs, which usually cause no symptoms.
The kidneys are often affected by the condition. Kidney failure is a concern among patients with this condition, and an early diagnosis is important to prolong the use of the kidneys. Early symptoms of kidney failure include blood in the urine.
The skin can also be affected by this rare disorder. The skin on the hands is often excessively wrinkled or loose, while the skin on the joints is unusually tight. This can cause extreme difficulty flexing the joints of the fingers.
Eye problems are a more serious complication of the condition. Glaucoma is a common concern among NPS patients. If left untreated, optic nerve damage and blindness can occur.
Skeletal problems are also common. Many patients experience bent or deformed fingers. The shoulder blades are often poorly developed, limiting movement. Unusual neck bones and scoliosis are often associated with nail patella syndrome. Clubbed feet and hip dislocations often occur as well.