VIPRE Antivirus Premium 4.0 was made available to add support to 64-bit edition of Windows 7, in addition to 32-bit edition of Windows XP, Vista and Windows 7, Server 2008, Server 2003 and Windows 2000 SP4. The install process of VIPRE continues to be straight-forward. The firewall and antivirus of VIPRE is fully integrated to Windows Security Center and Windows Action Center in Windows. It disables Windows Defender, if installed or enabled. VIPRE Antivirus Premium will only use 25.9MB of hard-disk space and require a PC restart after installation. A setup wizard is presented after the system restart to guide you in setting up VIPRE. The installer will not automatically detect what email client is installed but you have the option to select which email program is in use. After installation, the program will download the necessary risk definitions to start protecting the computer. Note that the Active Protection by VIPRE is disabled until the risk definitions has been downloaded and applied.