There are some cases where the other security features of Outlook just won't work. However, you may be able to use the blocking and allowing e-mail feature of Outlook. There are many ways of making this feature more practical to use. Obviously there are many approaches to using this security feature of Outlook.
The most practical use is to block (black list) individual senders or block a complete domain. Combine this with allowing (white listing) individual senders or a complete domain, and you have a very flexible compliment to Outlook's junk e-mail handling features.
Warning: If you think only allowing known senders and blocking all else is a good security solution, think again. If your contacts ever get compromised and starts sending e-mails to you, those e-mails will go right through since it is in Outlook's white list.