Really, a 2 Tb hard drive only requires a slightly beefier power supply, because any modern motherboard with SATA connectors and connections for power can make a hard drive work. Just connect the hard drive to both the power supply and the motherboard and it should all work.
On the odd chance that your motherboard doesn’t have a SATA connection, there are always IDE-to-SATA connectors that make the SATA cables play nice with an IDE connection. Keep in mind though, if you use this connector, you’ll need an additional power adapter to make the SATA work.
One thing to keep in mind is that with a large amount of space in the case of a 2 Tb hard drive, you’ll need extra RAM to be able to run everything you want at once. At bare minimum, the RAM requirement is about 2 Gb, but if you have a 64-bit processor, you might want to bump that number up to 4 Gb, it’ll work even better than with 2.
And that’s all there is to it – following the RAM and Power Supply Requirements, you should be ready to go even with your current motherboard. After all, money is hard to come by these days, and if you can use your existing setup, why bother changing anything at all?