D-Fend has a very nice and straightforward wizard to help you create a game profile.

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Let's see the steps. Pressing F3 or selecting Profile -> Add with Wizard, we start creating the profile for our game. We'll input a name for the profile. Let's say I input "pirates", because I want to play Sid Meier's all-time classic, and plunder the Caribbean, old-school style.
Then on the next screen we select the game executable. We probably don't need to run a setup executable first (usually to setup sound for the game), but if we do, we can also select one here.
The third screen is where we choose some readily available configurations for Dosbox. We can choose the "Use user-defined auto setup template" pull-down menu, which are ready templates for many well-known DOS games. Just pick the game title and you should be ready. Alternatively, we can use a more generic template from the "Use user-defined template" menu, like normal DOS games, simple DOS games, or complex DOS games. We can also use the default wizard template for an even more generic approach.

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In the next step we can fill our information to catalogue our game and not have to look through our whole list of game profile each time we want to play one.
Finally we check the list of mounted drive mountings that will be available when we run our game (or application). A drive mounting maps a directory or drive from our computer into a DOS directory or drive that will be available when we run our game. You shouldn't have to change anything here. Just click Ok and double click your newly created game profile to play.