This is just a series of varren attacks. I suggest you use the submachine gun though, since we might as well save the ammo for the good stuff. The only real trick is to order your squad to stand in the middle. If they're behind cover, then they'll only poke their heads out occasionally. We want them firing as fast as possible to put down the varren.

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I suggest that you just take up a spot by the keystone trigger. The varren come from all sides except the keystone, so if you can just keep an eye out you'll be fine. If one gets too close, then just melee it. If you run out of ammo, just look for a dead krogan. You should be able to pick up a lot of ammo from their bodies.
The second wave is made up of Klixen. It's basically the same. Keep your back to the keystone and just keep firing. They should just come in fairly organized waves, so you'll be fine. Just try to kill them before they get too close. That little explosion when they die is pretty nasty.
The third attack is the real challenge. It's a thresher maw. This is one tough beast. It can fire one large ball of acid at you and it is powerful enough to break down those freestanding steel towers. Don't take cover behind them. Just take cover behind the walls and the connected towers. The thresher maw itself is pretty tough, but you should be able to kill it. Just hammering it with a particle beam will take off at least half of it's health. Incinerate works well, too. Just use the ammo you have left in your heavy weapons to bring it down.
If worst comes to worse, you can just run around and hide for 5 minutes and you still win.
We're not all the way done yet. Uvenk will come and challenge Grunt. Note that his best concession is to turn Grunt into a trophy for the clan. Even if you're nice this will end in a battle. Just get behind a wall and start shooting. The guards should die pretty quickly. You've dealt with krogans before. Uvenk has a barrier, but it should also go down pretty quickly.