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Founded over a decade ago,
Penny Arcade has become much more than a web comic. There are games based off the Penny Arcade characters, all sorts of t-shirts, and even a gaming festival/convention known as the Penny Arcade Expo.
But it all started with the comic. Over the years, Penny Arcade's popularity has allowed them to become more and more experimental, and not all of the comics continue to be based off gaming. Still, they revolve around gaming culture and more importantly, they remain some of the best. The style of Penny Arcade, including its thick-lined characters placed over obscured backgrounds, is commonly mimicked among other video game comics, as is the typical three-pane presentation.
As mentioned, Penny Arcade's style is more experimental these days, but Penny Arcade's back catalog is readily available. The old comics still hold up today, and are worth checking out.