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Pistols fall into this category, although we've seen many especially weird or extraordinary variants in the genre. I skimmed through many a weapon's description trying to jog fond memories of keeping a kill streak going long after you run out of ammunition for your primary and resort to a pistol, or preferably, hand cannon. I found one recurring thing, one pistol that is so famous in FPS gaming that nothing could take it's place.
The Desert Eagle. The defining game, in this case, would be Counter-Strike: which ever version you perefer, although it has made appearance in way too many FPS games to count. Holds only 7 bullets, reload time is longer than the time needed to wash an elephant, and very inaccurate, but who cares? With 3 bullets, you can kill anything. Two, if aimed in the head. One, if the character was wounded. Use at your own risk, and enjoy the consequences. (I am going to disagree: not many guns get their own multiplayer mode, let alone are featured in a major motion picture title. How can 007's Golden Gun, between pedigree and one-shot one-kill efficacy, not get the nod? - Ed.)