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This is an absolutely vital element to every game you play. On this screen you can determine how your players will deal with each member of the opposing team. The danger men should be singled out here for special attention and it is a good idea to ensure that attacking players on the opposition side are always shown onto their weaker foot and closed down or marked.
If you are uncertain about what to do then click the Ask Assistant tab at the top right and he will pick for you. However, be warned, the assistant manager will often tell your players to go in hard on the tackle on certain opposition players and in my experience this leads to red cards so you might want to tweak his suggestions. Remember, like the rest of your tactics, these settings can be altered later so you can always try an approach and if it isn’t working change it.