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There are loads of items to find in Resident Evil 5 and so you should search every area thoroughly. There are boxes, chests, stone vases and various other containers that may be holding vital ammunition or gold. Smash them with your machete to save bullets. You’ll also find treasures that you can sell in the store to build up a bigger bankroll for the important purchases in life, like explosives or weapon upgrades.
You get a total of nine slots in your inventory so use them wisely. The best idea is to combine anything you can to save space. Since items that are the same can be combined make sure you consolidate them in one person’s inventory rather than splitting them between you. You should also make sure and leave some empty slots for the next level because it is very annoying to find pick ups and be unable to grab them. If you do find something you really want and swapping things around with your partner won’t create space then you may have to drop something you’ve decided is less useful.
You can organize your inventory, store and swap things and buy new items between each level. During gameplay you can still access your inventory but it happens in real time, it doesn’t pause the game, so be very careful about when you do it. You can quick select items from your inventory with the 1-9 number keys.