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For most people it is the multi-enemy fights that will pose the most serious challenge. Because you have more than one enemy against you, the defensive moves that seem so simple against a single opponent become much more complex and difficult to use correctly. You can't just shield yourself behind a block, and dodging can sometimes put you into as much danger as it gets you out of. These moves are still useful, but you need to rely on good-old fashion footwork as well. An enemy can't punch you if you're out of reach. Use this basic fact to your advantage.
Don't stand and fight if your enemies have you surrounded. Run! Your opponents will follow you, allowing you to keep them in your sight (if you run backwards) and in a predictable line, which makes pulling off defensive moves much easier. If you need respite from a barrage of blows, find cover behind buildings, statues, or whatever is available. Your enemies are not as quick as you, and you can run circles around them if you need too. The only thing you must be careful of when running about is an enemy with a ranged weapon, but you can take care of them quickly by sprinting in and hitting them with a charge attack.
Also, remember that you can kick enemies while they're down, and that an opponent sent flying through the air can knock down others. Every stunned enemy is an opportunity; if you take the poor sucker and throw him into his buddy's chest, you'll send both of them tumbling. This tactic will make your life much easier.