Level 8 Perks
Strong Back Requirements: Str 5 End 5- Allows you to carry 50 more pounds of equipment. If you're a Heavy Weapon nut, this is very useful. Otherwise, you can skip it.
Size Matters Requirements: End 5 - This gives you 15 points in the Big Guns skill, which makes this a very good skill for anyone using Big Guns. In fact, the strength of this perk is such that I recommend anyone looking for a secondary offensive skill pick up Big Guns. This can be ranked 3 times for a total of 45 skill points, which means it is very easy to max out the Big Guns skill.
Scrounger Requirements: Luck 5 - This helps you find more ammunition in containers than you normally would. If this was a level 2 perk, it would be great. At level 8 it isn't that good, since you're probably having a fairly easy time stockpiling ammo at this point.
Rad Resistance Requirements: End 5 - Gives you 25% rad resistance. Not very useful, considering how easy it is to buy Rad-away and Rad-X
Impartial Mediation Requirements: Cha 5 - Gives you 30 points in speech if your alignment is neutral. The problem is the game makes it difficult to make sure you are of any particular alignment, so its anybody's guess if you'll actually get to use the 30 points. Stay away from this one.
Commando Requirements: None - Increases VATS accuracy with two-handed ranged weapons like rifles. For anyone who is using Small Guns or Energy Weapons, this is an absolute must-have.
This is the first article in a series. The other articles will cover the other perks in Fallout 3, and the final article in the series will provide general tips about how to best allocate your available perks. Together, these articles will provide a comprehensive overview of all the perks available in Fallout 3.