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Defiance is an interesting passive in that it starts off weak (no resistance) but builds to very high values. As you are attacked (every 5, 4, or 3 seconds depending on rank), you gain stacks of Defiant! (up to a maximum of 8 stacks). The more stacks you have, the more damage resistance you have. Whenever you gain an additional Defiant! buff, it refreshes all existing ones as well. The amount of resistance gained from each Defiant! buff scales with your CONSTITUTION stat.
There are a number of powers that synergize with this one. Defensive Combo can add up to one stack of Defiant! simply by attacking with it (originally, the number of stacks from Defensive Combo was unlimited). Enrage converts all stacks of Defiant! into stacks of Enraged!, which can provide for a pretty significant damage buff.
This passive is good for long battles against powerful villains (especially cosmic and legendary rank). But the alpha strike could be brutal since you start off with no damage resistance.
STATS FOR SCALING: Constitution
Advantages of Note: Force of Will adds knockback and stun resistance as your health gets lower. This is interesting, since status protection powers are so rare in CO. But adding this resistance only when your health gets low is probably too late. The truth is, the only effective status protection is the block ability right now. That is the unfortunate truth of the matter.