With the Brute we’ve come to the first choice regarding the role you are to play. Do you want more direct survivability or more damage? Each secondary set will have their individual strengths and weaknesses and the choice you make will somewhat determine what teams expect of you. A damaging character will tend to play very much like a Scrapper, moving quickly from fight to fight, while a defensive centric Brute might spend more time drawing the attention of enemies rather than concentrating on defeating them. For our purposes the primary sets are still equal in strength.
If you are looking for a set that is more about keeping your allies alive a good rule of thumb is this: choose a set that contains powers that represent all three defensive styles. This seems to allow for better survivability. Alternatively, When making a Scrapper-like Brute, examine some of the non-defense powers that are included in the set. These powers are designed to enhance the Brute’s abilities and, in some cases, that means increasing their damage output or attack rate. Finally, know if your set has an endurance recovery power. Since every single defensive set includes multiple toggles that continually drain your endurance, the ones that also include endurance recovery or endurance discount powers will better help you keep going.