The characters in this episode of GTA 4 are much easier to connect with than those of The lost and the damned, or even GTA 4 Liberty City. Maybe I'm alone in this manner, but I feel the satire on the rich, capitalistic side of America strikes home much easier than the biker gang stories. That being said I was more empathetic towards Gay Tony than Niko, or those bikers; but maybe thats just me. Rockstar of course has put loads of production value into the story and animations, so expect a classic GTA experience.
The only con to this side of GTA 4 Liberty City is that there is so much animated sex. This isn't a bad thing, and I'm all for games taking a turn towards maturity, but the depecition of sex and execution of the animations are just so crude. We have a lot of catch up to do on the romantic side of video games. Just look at films, they inspire emotion, whereas video games just insipre comedic relief in this area.