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If you've played Resident Evil 4 or 5, then you'll feel right at home when you sit down to play Dead Space. However, there are some changes, so it's not entirely the same. First though, how does the game play for people who may not have tried Resident Evil 4 and 5?
The game sees you move Isaac Clarke around the Ishimura with the left analog stick, while the right analog stick controls the camera and weapon aiming. During the game, Necromorphs will attack your character and to combat them, you have various tools/weapons at your disposal. One difference from Resident Evil is that you need to aim for the creature's limbs to dismember them. Another difference is that you can actually move and fire at the same time, which is great.
The upgrade system from Resident Evil 4 and 5 is also present, though it's slightly different. Essentially, you can buy nodes or find them and then place them in various places on a circuit like interface, with some of the places giving bonuses to the weapon in question. The nodes can't just be placed anywhere either, as they need to be placed next to another one and there are normally several upgrade paths available. Also, credits can be used to buy items such as ammo.
Another difference from Resident Evil is the inclusion of zero gravity sections, where you can jump all over the place and enemies/items float in the air. It's not great, but it's not bad either. They don't come along very often either.