Once in microgravity, dramatic bone and blood volume loss, potential nausea, and extreme congestion are just the prelude to your experience. Thankfully, both anecdotal evidence and analysis of our accumulated time in manned space flight suggests that our bodies have a incredible capacity to adapt to those conditions, though we pay for those adaptations on our return to gravity. As concerns the long duration crew health and interaction facet, consider that the longest space mission to this point is 437.7 days, a record set by Valeri Polyakov, a Russian cosmonaut aboard Mir. This Mars mission would be longer by 240 days and involve multiple people interacting in an enclosed environment far from home. Crises involving small groups of humans in other dangerous environments highlight the potentially catastrophic effects of the interaction between mental pressures and physical danger. This is the reason why space programs choose their personnel in a manner very similar to nuclear submarine crews. As any college student who has had trouble with a roommate can tell you, close proximity has a way of magnifying character flaws and clashes, and there won't be much in the way of privacy during the mission!