Pramoxine can cause side effects. The common side effects often go away as the patient's skin becomes used to the medication, but if the side effects worsen or persist they should contact their physician. The common side effects include dryness at the area in which the medication is being applied. Other common side effects include redness, pain, irritation, stinging, burning, and sweliing at the site in which the medication is applied. Serious side effects are uncommon, but if they do occur patients should seek medical attention immediately. The serious side effects include bleeding at the site in which the medication is applied, hoarseness, hives, trouble swallowing, difficulty breathing, severe itching, skin rash, and swelling of the lower legs, face, ankles, throat, feet, tongue, eyes, hands, or lips.