Vaccinations had been implicated as a direct cause of various genetic diseases, including LNS. This is however a myth and unfounded based on recent scientific retrospective investigations.
As hyped by media in the Western world, vaccination for petrussis was thought to be the direct cause of encephalopathy with intellectual impairment and refractory seizures. An Australian study revealed findings that alleged vaccine encelopalopathy could be a genetically determined epileptic encelopalopathy that arises de novo. Furthermore, the study was conclusive that the brain disorder was not directly triggered by the vaccine for pertussis.
Another study by Berkovic and company studied 14 patients with alleged vaccine encelopalopathy with onset of seizures within 72 hours after vaccination. They found that 78 percent of the subjects had mutations in the SCN1A gene. Thus, the majority of these patients had clear genetic causes for the disease. In addition, vaccination cannot be blamed for causing the gentic mutation. According to the research, avoidance of immunization because it can potentially trigger mutation of SCN1A mutation or other types of genetic mutations does not make biological sense.
These studies hope to provide major implications for the public acceptance of vaccination as a safe way to prevent diseases. Like other genetic disorders discussed above, LNS cases due to de novo mutation of HPRT1 gene do implicate immunization as a direct cause. So, is the environment or vaccinations responsible for Lesch Nyhan syndrome? In this case, environmental factors play a role in this disease but reputable studies show that vaccination does not cause LNS.
