Most females are diagnosed during infancy or during early childhood, but in some cases, females are not diagnosed until they are adolescents or young adults. A late diagnosis usually occurs when the individual presents with mild symptoms.
Symptoms noticed at birth or during infancy include web-like or wide neck, delayed growth, small or receding lower jaw, height that is slightly shorter than average, roof of the mouth that is narrow and high, feet and hand swelling, low hairline on the back of the individual's head, upward-turned fingernails, drooping eyelids, cubitus valgus, widely-spaced nipples and broad chest, and short hands.
Those who only have mild symptoms, which are typically not noticed at birth, present with a different set of symptoms. These include no growth spurts during childhood, infertility and inability to conceive, short stature, an end to menstrual cycles, learning disabilities (particularly with math or spatial concepts), stalled sexual development, social difficulties, and failure to experience the sexual changes that should occur during puberty.
This disorder cannot be cured, but it can be treated. The two main treatments include growth hormone and entrogen therapy. Growth hormone is injected several days a week to help the patient experience growth spurts as they should. Estrogen therapy is administered throughout the patient's life, until menopause, to help her start puberty and reach normal sexual development as an adult. Women who experience infertility may seek fertility treatments to conceive children.