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There are probably several reasons why the bed bug genome has not been explored in any great detail. In the first instance we were perhaps a little complacent and underestimated the threat; bed bugs have not been a serious problem in urban environments for decades. And as they don't cause any diseases there has never really seemed to be a sense of urgency to get under their skin to find out how they work.
That'll teach us! It seems now that they are an unpleasant itch that just won't go away, so science is starting to turn its firepower onto the little beasties.
Since DDT was banned the weapon of choice has been pyrethroid insecticides which attack the bed bug nervous system, but increasingly the chemicals have been unable to contain some infestations.
Researchers from the University of Massachusetts Amherst and Korea's Seoul National University have been probing the little critters to find out how they've been able to develop resistance against the insecticides designed to destroy them. What they found were that genetic mutations in nerve cells somehow neutralise the effect of the pyrethroid toxins. The mutations affect sodium channels in the neurons' outer membrane so that they no longer respond to the paralytic effect of the insecticide. It's not sure how widespread this resistance is.
In other studies scientists from the University of Arkansas are looking at bed bug population genetics for insight into the genetic variation among populations that has lead to their dispersal, and resistance to insecticides.