Although it is a well known fact that tobacco smoking in any form is very dangerous for health, research has shown that only a small proportion (15%) of long term tobacco smokers have the tendency to develop lung cancer. But if you are a chain smoker and jump to the conclusion that smoking is safe, let me also tell you that clinical studies also document that smoking causes 90% of all lung cancers with the remaining 10% attributed to other causes.
These statistics can be answered in context of GxE although even now scientists cannot point towards specific sets of genes and how the environment interacts with them to promote lung cancer, or protect against it. However, extensive experiments in this arena have given some generic clues. For example, University of Texas researchers have identified nearly 50 genes on chromosome 6, which could be possible culprits for a particular type of lung cancer. Similar experiments are going on in several institutes and research labs across the globe in pursuit of more answers on the GxE front. In October 2008 research teams from the US and Germany published findings that they had identified 26 genes that when mutated lead to the most common form of lung cancer.
There might come a time in the future when you could simply get a test done from a medical laboratory (before you become addicted to the habit) to find out if you are susceptible to developing cancer from smoking. Though even if this were possible, doctors will always advise that the best way of eliminating the risk of contracting lung cancer from smoking is to do all you can to stay away from the habit.