Symptoms and How this Condition Affects the Body
Symptoms generally begin between birth and 25 years of age with the average onset being during the first two years of life. Male infants with this condition generally experience bleeding, commonly prolonged bleeding from circumcision, unusual bruising, bloody diarrhea and purpura. Intracranial hemorrhage may affect less than two percent of patients.
Infections may occur and generally begin in the first three months of life. Streptococcus pneumoniae may cause meningitis, pneumonia or sinusitis. Staphylococcus aureus and Haemophilus influenzae type B may also occur. Otitis media is very common, and patients are also at risk for viral and fungal infections.
Autoimmune diseases can occur at any age, with the most common being autoimmune hemolytic anemia. Glomerulonephritis may cause renal failure. Other possible issues may include neutropenia, skin vasculitis, inflammatory bowel disease, arthritis, cerebral vasculitis and renal disease.
Eczema may occur and is clinically similar to atopic eczema. It generally develops during the patient's first year of life. It may be worse when the patient is experiencing an infection. Allergic rhinitis and other atopic conditions may also occur.
Malignancy is more common in adults but may occur in children. Around 25 percent of patients with Wiskott-Aldrich syndrome older than 20 years of age develop lymphoma. Non-Hodgkins lymphoma is the most common malignancy, but leukemia may also occur.