Perhaps the biggest and most obvious resistance that you will encounter is going to come from your employees themselves. Most people do not like change. They are used to how things are done and want to keep it that way. Plus, a large percentage of your employees are not invested in the organization and are perhaps even trying to sabotage you. This resistance could lead to failure almost immediately.
Getting these people involved early and helping them understand why the change is necessary is probably the best way to deal with this situation. Make them an invested partner in the change and the motivators.
Many employees do not like change for the simple fact that they are not confident that they will be able to perform the new tasks satisfactorily. Give them plenty of training, and maybe even provide some one-on-one counseling to make them feel more comfortable with the new trajectory.
You need to also follow up with employees once the change has been implemented. Often, employees will fall back into their old routine, which could lead to failure.