Hi Josh....
There are lots of ways. WMV, MOV, Flash, AVI, MPG and other video file types can be made with quality settings of good, better, or best... with file sizes that go up with higher quality.
It starts with the software choices you already have, and your knowledge and skills to use them.
It's about finding your personal 'sweet spot'... the balance between quality and file size. What might be best for you isn't necessarily what's best for your viewers.
PapaJohn