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Chromosomal abnormalities are at the heart of genetics research. Of particular concern are sexual chromosomal deviations, such as Klinefelter's syndrome, due to the presence of another X (female) chromosome in the makeup of a male.
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Guide to Klinefelter's Syndrome

Chromosome StructureSexuality is important to most individuals. Ordinarily males possess an XY combination and females have an XX chromosome combination. Klinefelter's syndrome is a result of an additional X sex chromosome in the male—XXY. This condition can be diagnosed via a test procedure called a karyotype, which falls within the purview of a cytotechnologist. Klinefelter's syndrome can produce a host of undesirable effects, including hypogonadism (small testicles) and gynecomastia (an excess of breast tissue). There are other secondary sex characteristics and social impairments. What do these include, and what can be done to assist sufferers? Answers to such questions may be found in informative Bright Hub articles.

Chromosome Structure: Credit: U.S. National Library of Medicine

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More About Klinefelter's Syndrome
Sex Chromosome Abnormalities

Sex chromosome abnormalities are by far the most common forms of chromosomal abnormalities as they rarely cause life-threatening diseases. Some of the most common conditions and their...

 Genetics Careers: the Cytogenetic Technologist

Cytogenetic technologists are laboratory workers who analyze human chromosomes—both healthy and abnormal—with relation to disease. Abnormal chromosomal condition and abnormal...