Because of the huge ranges they require, they are acutely sensitive to habitat loss and fragmentation. Most national parks are too small to even begin to satisfy a pack of these relentless predators. Also, because of this reduced range, where previously many large carnivores coexisted in relative peace over the expanses of Africa, there is now frantic competition for many of the same prey species. Lions will even seek out African Wild Dogs to kill.
The isolation of many of the packs from each other due to intervening human development, as well as the increasingly cramped ranges forced upon them by the drawstring of development, make them more susceptible to viral diseases, such as rabies and distemper: local extinction is an ever-present threat. There are some veterinary programs in place to attempt to improve their immunity to such diseases.
African Wild Dogs are also extensively hunted by local livestock herders and game hunters. Many conservationists have suggested that this is largely due to the bad connotations of their common name, and so propose that they should instead be referred to as the Painted Hunting Dog, which is somewhat more pleasing to the ear. This has had limited effect, and many are skeptical as to the effectiveness of such a change. There are also many efforts to work with locals to conserve African Wild Dog habitat.
Of course, the African Wild Dog doesn't get nearly the publicity of other African carnivores. The lion is romanticized throughout Western civilization, the cheetah renowned for its feline grace. Even the hyena, famous for its eerie laughter, gets is share of conservation efforts. However, the somewhat comical appearance of the African Wild Dog makes it a difficult subject to raise money for.
African Wild Dogs are principally researched as part of the continuum of African predators in the Botswana Predator Conservation Trust (BPCT.) Conservation groups focusing on the African Wild Dogs include the African Wild Dog Conservancy and the Namibia Nature Foundation's Wild Dog Project–check out any of them and see what you can do to help!