There are a variety of ways you can make all-natural and environmentally friendly toothpaste, usually based on preference. If you want to make a cinnamon flavored toothpaste you really tap into the cleaning power of baking soda by mixing a teaspoon of baking soda, a quarter teaspoon of cinnamon, and a drop or two of Tee Tree Oil. You can make mint toothpaste by mixing half of a teaspoon of baking soda, half of a teaspoon of sea salt, a drop of clove oil and two drops of mint oil.