Have the students read the novel in class. You will be surprised how quiet the room becomes when special education students discover the joy of reading. This is a book for juniors or seniors due to the content. If you have block scheduling, so class periods are long, plan on 50 to 60 minutes of silent reading. That's right. The students don't want to put the book down.
Prepare the students for the story by doing background on the Holocaust. Actually, this is a great book to use in a history class or a history/English class. Students need plenty of preparation with the history. Otherwise, they will have difficulty with the understanding of the Nazis. In the story, Jewish people are mice and the Nazis are cats. This is an excellent book to use for simplistic studies on symbolism, as well.
Prepare the students for reading a graphic style novel. Surprisingly, many students are not familiar with comic books, so they don't understand how to read the conversation and how to follow the graphics.
Use discussion. This book is great to talk about father and son relationships, internal conflict, the generation gap, stereotyping, and of course the history of the Holocaust. There is a plethora of subject material to make this a great literature or history unit. Check out MAUS Resources for more ideas.