Another important thing to touch on when teaching Mrs. Frisby and the Rats of NIMH is the universal themes in Robert C. O'Brien's book:
Friendship: Sometimes, the most unlikely of characters, people, or in this case, species can become friends. In this book, Mrs. Frisby doesn't think she can trust the rats, but then she has no choice but to turn to them. She discovers that her husband had befriended them and that she can also trust them. You and your students can discuss who are true friends in this novel and what friendship means. What does it mean to be a true friend?
Loyalty and Trust: Friendship, loyalty, and trust go hand-in-hand, and that's especially true in this middle-grade novel. Mrs. Frisby has to learn to trust the rats no matter what she thinks of them at the beginning. Nicodemus, the lead rat, decides to help Mrs. Frisby because of his loyalty to her husband. You can discuss with your students or your child what loyalty means to the characters in this book. You can also ask students about how the characters gain each other's trust.
Overcoming adversity: Mrs. Frisby is alone and must move her children to keep them safe from the farmer's plow. However, her son is ill, and she can't move him. Does she give up? No, she finds a way to overcome adversity and save her family. This theme can give students encouragement to try and do things they want or need to do even when it feels impossible to them.
Heroism: In today's society, we often call people "heroes" who don't have very "hero-like" behavior. So, the first thing to do when discussing this theme is to define what a hero truly is with your students or your child. Then talk about the characters in the story and see if they think any of them display hero-like behavior.