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Should Internet Explorer be failing to run in anything other than Safe Mode, it could be that an infection and subsequent fix by your anti-virus software has resulted in corrupted Winsock settings. Alternatively some piece of malware (malicious software) that your AV utility isn’t designed to detect has interfered with your browser.
Before proceeding, you should check your Windows Update routine – while you might be unable to connect to the web to download any fixes immediately, you will need to ensure that as soon as everything is back up and running you run the updates tool to pickup and apply and Microsoft security fixes.
Winsock defines how all Windows–based network software should access network services, and concerns itself particularly with TCP/IP, the protocols used to find and load web pages and other web based content.
If Internet Explorer is unable to find the Winsock settings when launched, this causes an error and forces the browser to launch into Safe Mode – this is because the Winsock configuration settings are vital to Windows correctly connecting to the web.