Based on common entry points of malware as well as footprints including, but not limited, to obfuscation, encryption and compression Mandiant Red Curtain calculates a threat score for files and folder it analyzes. The higher the threat score the higher the probability that a certain file or executable is malware.
Reported suspicious files must be further examined and analyzed though, but this a common a situation for people trained in incident response, and, in fact, the nature of the game and not a deficit of the software.
Thus, MRC can be a free helpful tool, and the software ships with an agent for data collection without the need for the full install of Mandiant Red Curtain on a remote machine.