The article How to Choose an Anti-Virus Solution should provide you with some pointers.
Definitely look for a solution that can be centrally managed. The bulk of the total cost ownership (TCO) of any security product is not its acquisition/licensing costs, but its administration costs - and choosing a product which can be centrally managed will enable you to keep those costs to a minimum. Furthermore, going with a centrally managed solution will also enable you to eliminate security holes by providing you with a mechanism to ensure that each of your endpoints complies with your security policy.
When choosing, it's important to remember that not all solutions are created equal when it comes to ease of management. While some may be extremely effective at stopping malware, they can also be extremely difficult to configure and manage (Symantec Endpoint Security definitely falls into this category). This is an important consideration for small businesses - especially for those without a dedicated IT staff - so read some reviews and trial some products before making a final decision.
BitDefender's business products are, IMO, a good choice; they're extremely effective, competitively priced, easy to manage and can provide integrated protection against a range of threats.