SAS let you integrate itself to Windows Security Center, start the program during Windows startup, show SAS icon in notification are in Windows, auto-scan during Windows start-up, check for updates before scanning on system startup, keep detailed logs and reset program options to its default. SAS allows you to scan a file or folder via context menu. However, SAS is required to be running.
SAS includes an option to start the program using Alternate Start. This is designed to allow the program to start if a malware is targeting SAS (which is common nowadays!) by blocking the malware scanner in running. Note that if Alternate Start will again prevent to the program to run, the vendor is offering a download version of SASSAFERUN.COM and RUNSAS.EXE. SAS includes a utility called BootSafe. This is not required in using the program (see FAQ about BootSafe utility in SAS) but available for users who want to quickly boot the system in safe mode.
MBAM has no program options other than save the log automatically after the scan and scan a file or folder via context menu. You do not need to have MBAM program running to use the single file or right-click scanner. If a malware is targeting MBAM (by blocking it from running or scanning), your option is to try running MBAM in safe mode or by renaming MBAM executable to something else.