As Internet access became more and more widespread, and the bandwidth of Internet connections increased, the ability of viruses to spread faster than any human disease became the norm. In 2001 the Nimda virus used multiple methods of infection, and was one of the most rapidly spreading viruses ever seen. It also infected more systems than possibly seen before. Total infection counts are always estimates, however.
As Web sites proliferated they also became more sophisticated and often used for online commerce. This required databases, and on Microsoft server systems the common database was and is Ms. SQL Server. The SQL programming language became a vector for virus infection by SQL code injection. Desktop computers often held a small simple version of the SQL core, and this too could be infected. Viruses such as SQL Slammer in 2003 spread rapidly and were notable for their tiny size, composed of SQL code.
Recently, (in 2008) there was much news and hype about the Conficker Worm. It didn't turn out to be as bad as expected regarding its planned attack from infected systems on a particular date due to the preparations of ISPs. See my articles on the Conficker worm and how to protect against it to learn more.