Good current anti-virus, security protection software, along with network firewalls or personal firewalls will provide excellent protection against worms. Just be sure to keep the software updated. This is what we mean by updating your virus or malware descriptions. Other things to keep in mind to protect yourself--and these are good ideas any time:
Don't click on a link if you don't know what it is.
Don't run or install a program if you don't know what it is and trust the source.
Don't just click OK without understanding what you're agreeing to.
Now you have a better idea what a worm is and how it propagates. For more help staying safe online, check out my article The Top 5 Security Mistakes People Make when Browsing the Web and How to Protect Against the Conficker Worm.