The first step in designing desktop computer security is understanding actions employees are or are not allowed to perform on company-owned equipment or with company-owned services. A description actions allowed, prohibited, or allowed under specific conditions is contained in an acceptable use policy. (Download a sample acceptable use policy.)
Employees must be aware of the contents of the acceptable use policy. Ideally, the do's and don'ts contained within it are included in a documented security awareness training program. Further, fair and consistently applied sanctions for not adhering to security policy should be in place.
Another important set of policies should describe the organization's approach to configuring and implementing end-user devices. One of these documents should include change and configuration management expectations intended to ensure secure system rollouts with little risk of breaking one or more business processes.
Finally, be sure all policies are supported by documented procedures. It's the procedures that ensure all desktops are configured and secured consistently, in accordance with management's expectations.
For more information on policies, see Security Basics - Overview of the Security Program and Security Basics - Components of Security Policies.