The split in the middle is much thinner than older styles of ergonomic keyboards, so even if this is your first ergonomic keyboard, there isn't a huge learning curve. They keys are much quieter than many other ergonomic keyboards. It really does keep hands in a natural position. I noticed far less discomfort in my wrists and arms after switching to this keyboard from my old one.
I don't recommend trying this, but I spilled half a bottle of water directly onto my 4000 about seven months ago. It died immediately. I unplugged it, dried it off, and placed it keys-down on a towel. After a few days it had dried completely. I decided to plug it in and give it one more try before tossing it and it has been working perfectly fine ever since.
This keyboard has a few small downsides. The key placement is a bit different from other keyboards. Many users, myself included, have complained about right hand punctuation keys. For some reason they're very easy to miss when you're typing. It takes a bit of getting used to before you can type a period instead of a comma on purpose. The backward tilt can be impossible for some people to get used to. I like it, but even I remove it sometimes. The good part is that it's removable and the keyboard has feet on the bottom so you can tilt in the normal manner if that's what you prefer. My A and S keys wore off in a matter of months. I have never had that problem with a keyboard before, but I've also never dumped a bottle of water on my keyboards either. The quick wear might not be a common issue.