The first thing to remember is to use the portable hard drive as a storage device, not as a reference memory location. What this means is that all work needs to be done and saved on an internal hard drive and then moved over to the portable hard drive once you are done. For example, if you are doing some video editing you need to set a scratch folder on the internal hard drive each time when you are working. Save it there, then save a copy onto your external hard drive. Next time you go to work on that project go to the file you saved on your external and open it, then set the scratch drive on the internal hard drive again. This will help to not burn out your external hard drive. Each time you do a casual save it has to go through all the motions, which is likely too much for your portable. Save it for only the big saves at the end of work time or when backing up your work.